Evolysse™
by Evolus®

EVOLYSSE™: Why Next-Generation Dermal Fillers Matter for Your Medical Practice

Medical practices face increasing patient demands for natural-looking aesthetic outcomes. Today’s patients arrive more informed than ever before, researching treatment options extensively before consultation. They seek results that enhance their appearance without sacrificing authenticity or natural movement. This creates a significant challenge for medical professionals: delivering consistently excellent outcomes that meet these heightened expectations.

Traditional injectable hyaluronic acid (HA) fillers often present limitations in dynamic facial areas. Medical professionals frequently report compromises between achieving desired volume and maintaining natural movement, especially when treating nasolabial folds and other expressive facial regions. When patients express dissatisfaction with results that appear “overdone” or feel unnatural during facial expressions, it impacts both patient retention and practice reputation.

The connection between effective aesthetic products and medical practice success extends beyond individual treatments. Each patient interaction represents potential long-term value, with satisfied patients returning for maintenance treatments and referring colleagues and friends. Conversely, suboptimal results may lead to costly corrective procedures, decreased trust, and potential reputation damage in today’s review-driven marketplace.

Understanding the HA Dermal Filler Market Evolution

The dermal filler market has undergone significant transformation since the first FDA-approved hyaluronic acid fillers became available in the early 2000s. Initially, products emphasized volume correction, sometimes at the expense of natural movement in dynamic facial areas. As patient expectations evolved, the demand for more sophisticated solutions increased.

Medical professionals understand this evolution well. Early-generation HA fillers presented several limitations:

1. Limited Tissue Integration: Some products remained distinct from surrounding tissue, potentially creating palpable or visible irregularities in certain areas.
2. Restricted Movement in Dynamic Zones: Particularly in highly mobile areas like nasolabial folds, traditional fillers could sometimes restrict natural facial expressions.
3. Suboptimal Longevity: Product degradation sometimes occurred unevenly, leading to unpredictable duration of results.
4. Manufacturing Processes: Traditional manufacturing methods subjected HA molecules to conditions that could potentially alter their natural biological characteristics.

Recent years have seen HA dermal filler manufacturers focus on addressing these challenges through advanced research and development. However, until now, most improvements have been incremental rather than revolutionary. Medical professionals and patients alike have anticipated a more significant leap forward in hyaluronic acid science that would maintain correction while enhancing natural movement and feel.

The Science Behind Hyaluronic Acid Fillers

Hyaluronic acid is a naturally occurring substance in the human body that provides volume, hydration, and structure to the skin. Its remarkable capacity to bind water molecules—up to 1,000 times its weight—makes it an ideal substance for addressing volume loss and supporting dermal structure.

In dermal fillers, the natural hyaluronic acid undergoes crosslinking—a process that connects the HA molecules to create a stable gel matrix that resists rapid degradation by the body’s natural enzymes. The specific crosslinking methods, concentration of HA, and manufacturing processes significantly impact the final product’s characteristics, including:

• Firmness and malleability
• Lifting capacity
• Tissue integration
• Longevity
• Natural feel during facial expressions

These characteristics ultimately determine how the filler performs in various facial regions and how naturally it moves with the patient’s expressions. The ideal filler maintains volume correction while preserving natural facial dynamics—a balance that has proven challenging to achieve consistently with traditional technologies.

How Evolus® Redefines Injectable Hyaluronic Acid Science

Against this backdrop of incremental advancements, Evolus® announces the official launch of their groundbreaking product. The new offering represents the first major technological breakthrough in HA dermal fillers in a decade. This revolutionary platform represents a significant advancement in the HA dermal filler market, utilizing proprietary Cold-X™ Technology designed specifically to preserve the natural HA structure, addressing longstanding challenges in achieving natural-looking results that feel natural in the facial tissue when treating wrinkles and folds.

The Technological Breakthrough Behind Cold-X™

The development of Cold-X™ Technology began with a fundamental question: How can manufacturing processes better preserve the natural characteristics of hyaluronic acid? Traditional crosslinking methods often expose HA molecules to conditions that can potentially alter their biological properties.

The research team at Symatese, through an exclusive agreement with Evolus®, explored alternative approaches that would maintain the essential structure of hyaluronic acid throughout processing. After extensive research and development, they created a proprietary method that:

1. Optimizes Temperature Conditions: By processing the hyaluronic acid under carefully controlled temperature parameters, the technology maintains more of the molecule’s natural structure and properties.
2. Enhances Crosslinking Precision: The method creates more consistent and controlled connections between HA molecules, resulting in a more uniform gel matrix.
3. Preserves Biological Compatibility: By maintaining more of the hyaluronic acid’s natural characteristics, the resulting product integrates more harmoniously with the body’s tissues.
4. Balances Stability and Flexibility: The technology achieves the crucial balance between longevity and natural movement that has been challenging to attain with traditional methods.

The Revolutionary Cold-X™ Technology Explained

Cold-X™ Technology represents a fundamental shift in how injectable hyaluronic acid gels are manufactured. Traditional manufacturing processes subject HA molecules to conditions that can potentially alter their natural structure. Cold-X™ Technology, through an agreement with Symatese, takes a different approach by:

• Utilizing lower temperature processing methods that maintain molecular integrity
• Preserving the natural structure of the HA molecule during crosslinking
• Creating a gel matrix that integrates more harmoniously with facial tissue
• Enhancing flexibility in dynamic areas of the face while maintaining volume

This technology, specifically aimed at preserving the natural structure of hyaluronic acid, allows the injectable hyaluronic acid made with Cold-X Technology to be designed to feel natural when used to treat wrinkles that form in dynamic areas of the face.

EVOLYSSE™ Collection: Form, Smooth, and Lift Options

The EVOLYSSE™ collection includes the first two products to receive FDA approval, with additional options to address different facial rejuvenation needs:

EVOLYSSE™ Form: Specifically developed for moderate to severe facial wrinkles and folds, including nasolabial folds. This smooth injectable hyaluronic acid gel provides structural support while maintaining natural movement in form in dynamic areas.

EVOLYSSE™ Smooth: Designed for areas requiring subtle enhancement with exceptional integration into surrounding tissue. This formulation of smooth injectable HA gels excels in regions where maintaining natural movement is paramount.

EVOLYSSE™ Lift: Completes the EVOLYSSE™ collection with specialized properties for areas requiring both lift and volumization while preserving natural facial dynamics.

Each of these two injectable HA gels leverages Cold-X™ Technology to achieve results that previous generation fillers like Restylane-L struggled to balance: effective correction with natural feel and movement.

Clinical Evidence Supporting EVOLYSSE™ Effectiveness

In a recent press release, Evolus® announces FDA approval of EVOLYSSE™ Form and EVOLYSSE™ Smooth injectable hyaluronic acid gels following rigorous clinical evaluation. The NLF pivotal study included 140 patients and showed statistically significant differences in treatment outcomes compared to control products, including:

• High patient satisfaction rates at 6 and 9 months post-treatment
• Favorable safety and effectiveness profile with no serious adverse events reported
• Consistent performance across diverse patient populations
• Impressive longevity of results while maintaining natural appearance

Dr. Rui Avelar, Chief Medical Officer at Evolus®, emphasizes that “EVOLYSSE™ represents the culmination of years of research aimed at preserving the natural structure of hyaluronic acid throughout the manufacturing process, resulting in EVOLYSSE™ fillers that perform exceptionally in dynamic facial areas. The ability of these products to maintain their integrity while allowing natural movement is a direct result of our reliance on Symatese to achieve this technological breakthrough in HA dermal fillers.”

What Medical Professionals Need to Know About These Advanced Fillers

Understanding the Clinical Applications and Benefits

The new collection from Evolus® brings several distinct advantages to medical practices seeking to elevate their aesthetic offerings:

1. Superior Performance in Dynamic Areas: The preservation of the natural HA structure results in fillers that move more naturally with facial expressions, particularly beneficial in treating nasolabial folds and other expressive regions.
2. Enhanced Patient Experience: Patients report that these advanced fillers feel more natural within facial tissue, potentially increasing satisfaction and loyalty.
3. Versatile Treatment Options: With multiple formulations available, medical professionals can select the optimal product for each patient’s unique needs and treatment areas.
4. Competitive Differentiation: Offering next-generation technology provides medical practices with a meaningful distinction in the competitive aesthetic marketplace.
5. Trusted Development: Created through Evolus®’ strategic partnership with Symatese, a renowned leader in biomaterial innovation, ensuring quality and scientific rigor.

Practical Implementation in Clinical Practice

Medical professionals considering incorporating these advanced fillers into their practice protocols should understand several key aspects of implementation:

Injection Technique Considerations

While the fundamental injection techniques used for these new-generation fillers remain consistent with established methods, practitioners may notice differences in:

• Extrusion Force: The rheological properties of these gels may differ from those of previous generation products, potentially requiring slight adjustments to injection pressure.
• Distribution Behavior: The enhanced tissue integration properties may affect how the product disperses following injection, allowing for more refined placement and potentially requiring less product to achieve desired outcomes.
• Malleability Window: The post-injection period during which the product can be molded may differ from that of traditional fillers, requiring appropriate timing adjustments when shaping the implanted material.

Experienced injectors typically adapt quickly to these nuances after treating their first few patients. Many report that the improved consistency and predictability of these advanced formulations actually simplifies the injection process once they become familiar with the products’ handling characteristics.

Patient Selection and Education

Optimal candidates for these new fillers include:

• Patients seeking natural-looking correction of moderate to severe facial wrinkles and folds
• Individuals who are concerned about maintaining natural facial expressions
• Those who have expressed dissatisfaction with previous filler treatments due to unnatural feel or appearance
• Patients with highly mobile facial features where traditional fillers may have produced suboptimal results

When discussing these advanced options with patients, medical professionals should emphasize:

• The technological innovations distinguishing these products from previous generation fillers
• The specific benefits of preserved natural HA structure in terms of feel and movement
• Realistic expectations regarding outcomes, longevity, and post-treatment appearance
• The importance of skilled administration by qualified medical providers

Providing educational materials that explain the science behind these advancements in terms accessible to patients helps build confidence in both the product and the practitioner’s expertise.

FDA Approval and Safety Profile

The FDA approval of EVOLYSSE™ Form and EVOLYSSE™ Smooth injectable hyaluronic acid gels validates both their safety and effectiveness for use in the U.S. market. The clinical studies supporting approved EVOLYSSE™ showed:

• Consistent performance across diverse treatment areas
• Well-tolerated by patients with minimal adverse events
• Results that maintained their integrity through facial movement
• Natural integration with surrounding tissue

As with all injectable HA gels, medical professionals should review complete safety information and contraindications before use of these products. EVOLYSSE™ is contraindicated for patients with severe allergies, and safety for use during pregnancy or while breastfeeding has not been established. Additionally, patients should be advised to report any unusual pain during or shortly after treatment, and the product should be used with caution in patients taking medication that can prolong bleeding.

Expert Perspectives on EVOLYSSE™

David Moatazedi, President and CEO of Evolus®, states: “The launch of EVOLYSSE™ represents a significant milestone for Evolus® and for the aesthetics industry. We’ve delivered the first major technological breakthrough in HA dermal fillers in a decade, providing medical professionals with next-generation hyaluronic acid injectable gels powered by cutting-edge Cold-X™ Technology to achieve exceptional results for their patients.”

Medical professionals from Newport Beach who participated in clinical trials report that EVOLYSSE™ products offer improved moldability and integration compared to previous generation fillers. “These injectable gels powered by cutting-edge Cold-X™ Technology allow us to achieve natural-looking results when treating facial wrinkles and folds, representing a meaningful advance in how we approach facial rejuvenation,” noted one leading aesthetic specialist.

Addressing Common Questions About Next-Generation Fillers

How Does Cold-X™ Technology Compare to Traditional Methods?

Medical professionals frequently ask how this innovative technology differs from conventional approaches to HA filler manufacturing. The key distinctions include:

Temperature-Controlled Processing: Unlike traditional methods that may expose hyaluronic acid to higher temperatures during production, Cold-X™ Technology maintains lower, controlled temperature parameters throughout manufacturing. This preservation of the natural HA molecule structure contributes to the product’s distinctive performance characteristics.

Molecular Integrity: The technology is specifically designed to preserve the natural structure of the HA molecule during crosslinking. This results in a more biologically compatible gel that integrates more harmoniously with facial tissues.

Balanced Performance: Products developed with this technology achieve an optimal balance between structural support and natural movement—a combination that has proven challenging with conventional manufacturing methods.

Tissue Integration: The preserved molecular structure facilitates enhanced integration with surrounding tissues, contributing to a more natural feel and appearance.

When Should These Advanced Fillers Be Recommended?

Understanding the optimal applications for these next-generation products helps medical professionals make appropriate recommendations for their patients:

Dynamic Facial Areas: These fillers are particularly well-suited for regions with significant movement, such as nasolabial folds, marionette lines, and areas around the mouth.

Patients Prioritizing Natural Results: For patients who express concerns about maintaining natural expressions or those who have experienced “stiff” or unnatural results with previous fillers.

Combination Treatments: These products work exceptionally well as part of comprehensive facial rejuvenation protocols, complementing other aesthetic treatments like neurotoxins, energy-based devices, and topical skincare.

First-Time Filler Patients: The natural-feeling results can help build confidence in patients new to injectable treatments, potentially increasing satisfaction and retention.

How Do These Products Integrate with Existing Protocols?

Integrating these advanced fillers into established treatment protocols is straightforward for experienced practitioners:

Assessment Approach: The fundamental patient assessment process remains consistent, focusing on facial anatomy, volume loss patterns, skin quality, and patient goals.

Injection Technique: While the basic injection techniques are similar to those used with traditional HA fillers, practitioners may notice differences in extrusion force and product distribution that typically require minor adjustments.

Product Selection: Understanding the specific characteristics of each formulation in the collection allows practitioners to match the appropriate product to each treatment area and correction need.

Follow-up Protocols: Standard follow-up timelines apply, though practitioners report that the consistent performance of these products may allow for more predictable maintenance scheduling.

What Patient Education Resources Are Available?

Effective patient education enhances satisfaction and builds trust. Resources available through Pipeline Medical include:

Before and After Galleries: Comprehensive collections of clinical images demonstrating results across diverse patient populations and treatment areas.

Technology Explainers: Patient-friendly materials explaining how Cold-X™ Technology differs from traditional approaches and the benefits this provides.

Treatment Planning Guides: Resources to help patients understand the comprehensive approach to facial rejuvenation and how these advanced fillers contribute to overall outcomes.

Post-Treatment Care Instructions: Detailed guidance for optimal recovery and result longevity following treatment with these next-generation products.

How Pipeline Medical Transforms Your Access to EVOLYSSE™

Streamlined Procurement Through Our Trusted Marketplace

Pipeline Medical‘s marketplace simplifies access to EVOLYSSE™ products through our specialized supply chain procurement platform. Our streamlined system eliminates traditional procurement challenges by:

• Providing reliable access to the complete EVOLYSSE™ collection
• Ensuring authenticity through direct sourcing relationships
• Streamlining ordering processes to reduce administrative burden
• Supporting medical practices with specialized product knowledge
• Offering efficient delivery to maximize practice productivity

Integrating EVOLYSSE™ Into Your Practice Protocol

Medical professionals can maximize the benefits of EVOLYSSE™ by:

1. Patient Selection: Identifying candidates who will benefit most from the natural movement characteristics of Cold-X™ Technology.
2. Treatment Area Optimization: Utilizing EVOLYSSE™ Form for nasolabial folds and other structural correction needs, while selecting EVOLYSSE™ Smooth for areas requiring subtle enhancement with maximum natural integration.
3. Combination Treatments: Exploring synergistic protocols combining EVOLYSSE™ products with complementary aesthetic treatments for comprehensive rejuvenation.
4. Patient Education: Communicating the technological advantages of EVOLYSSE™ to increase perceived value and differentiate your practice offerings.
5. Results Documentation: Capturing before and after imagery that demonstrates the natural-looking outcomes achievable with EVOLYSSE™ products.

Support Resources for Medical Professionals

Pipeline Medical offers comprehensive support for medical practices implementing EVOLYSSE™ into their treatment protocols:

• Educational resources about Cold-X™ Technology and its clinical applications
• Practice integration guidance from our specialized medical supply team
• Efficient procurement processes to ensure consistent product availability
• Expert consultation on complementary products to enhance patient outcomes

Why EVOLYSSE™ Represents the Future of Facial Rejuvenation

Technological Innovation Driving Clinical Outcomes

The development of Cold-X™ Technology demonstrates how fundamental innovation can address longstanding challenges in aesthetic medicine. By preserving the natural HA structure, EVOLYSSE™ creates new possibilities for:

• Treating facial wrinkles and folds in highly dynamic areas
• Achieving natural-looking results that move with facial expressions
• Maintaining correction while enhancing, rather than restricting, facial movement
• Delivering patient satisfaction through results that feel natural in facial tissue

Setting New Standards for Natural-Looking Results

EVOLYSSE™ raises expectations for what patients and providers should expect from dermal fillers:

• Results that remain natural through the full range of facial expressions
• Enhanced tissue integration for improved feel and appearance
• Longevity without compromising natural facial dynamics
• Versatility across different treatment areas and correction needs

Evolus®’ Commitment to Advancing Aesthetic Medicine

The introduction of EVOLYSSE™ builds upon Evolus®’ established position in aesthetic medicine, following their successful launch of Jeuveau®, the first and only neurotoxin dedicated exclusively to aesthetics. This pattern of innovation demonstrates the company’s commitment to developing specialized solutions for aesthetic practitioners and their patients.

Through their strategic reliance on Symatese to achieve regulatory approval for this technological breakthrough in HA dermal fillers, Evolus® continues to demonstrate their focus on bringing meaningful advancements to the medical aesthetics community.

Transform Your Practice’s Aesthetic Offerings With EVOLYSSE™

The introduction of EVOLYSSE™ Form and EVOLYSSE™ Smooth injectable hyaluronic acid gels powered by cutting-edge Cold-X™ Technology represents a significant opportunity for medical practices to enhance their aesthetic services. By offering EVOLYSSE™ Smooth and EVOLYSSE™ Form, these next-generation products developed by Symatese, practices can:

• Deliver superior outcomes in challenging dynamic areas of the face
• Increase patient satisfaction through natural-looking results that feel natural in the facial tissue
• Differentiate from competitors with a truly innovative product designed to preserve the natural HA structure
• Build practice reputation through exceptional aesthetic outcomes

Discover how Pipeline Medical’s marketplace can streamline your practice’s procurement process for the EVOLYSSE™ collection. Access FDA-compliant medical-grade products through our supply chain procurement platform to enhance your practice’s capabilities and patient satisfaction.

The information provided on this site is for informational purposes only and is not intended to substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider or medical professional for guidance on any medical concerns, product use, or treatment decisions.